DARTpaths, an in silico platform to investigate molecular mechanisms of compounds
| ResearchComponents.InformationTable.Publication.Authors | Diksha Balla, Marvin Steijaert, Eefje Poppelaars, Marc Teunis, Monique van der Vloet, Marie Corradi, Elisabeth Dévière, Luuk Noothout, Wilco Tomassen, Martijn Rooseboom, Richard Currie, Cyrille Krul, Raymond Pieters, Vera van Noort, Marjolein Wildwater |
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| ResearchComponents.InformationTable.Publication.PublishedIn | Bioinformatics |
| ResearchComponents.InformationTable.Publication.PublicationDate | 2023 |
| ResearchComponents.InformationTable.Publication.Lectorates | Innovative Testing in Life Sciences and Chemistry |
| ResearchComponents.InformationTable.Publication.PublicationType | Article |
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Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied to predict developmental and reproductive toxicity (DART) and implemented into an in silico platform, called DARTpaths.
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| ResearchComponents.DetailedInformation.Language | English |
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| ResearchComponents.DetailedInformation.PublishedIn | Bioinformatics |
| ResearchComponents.DetailedInformation.YearAndVolume | 39 1 |
| ResearchComponents.DetailedInformation.Keywords | developmental and reproductive toxicology (DART), algorithms, software |